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Ari Selzer, a student in the MBSB Program, successfully defended his thesis on August 9th to complete his Ph.D. The title of his presentation and thesis is “Allosteric Modulation of Src-Family Kinases in Acute Myeloid Leukemia: Harnessing Natural Mechanisms of Kinase Regulation to Develop Novel Therapeutics”. Ari performed this research under the supervision of Prof. Thomas Smithgall in the Department of Microbiology and Molecular Genetics at University of Pittsburgh School of Medicine. His project combined multiple biophysical approaches to better understand small molecule modulation of a cancer-associated kinase, including x-ray crystallography, protein NMR, and hydrogen-deuterium exchange mass spectrometry. Ari will begin a postdoctoral fellowship in the laboratory of Dr. Catherine Drennan at the Massachusetts Institute of Technology/HHMI later this fall and plans to follow a career in academic research.\\

Congratulations, Ari!

Please check the student and faculty websites;

https://www.mbsb.pitt.edu/index.php/site-map/articles/85-students/282-ari-selzer

https://www.mbsb.pitt.edu/index.php/site-map/articles/81-faculty/185-thomas-smithgall

By MBSB.