20241011
Application of artificial backbone connectivity in the development of metalloenzyme mimics;
Wolfe JA, Horne WS. (2024) Curr Opin Chem Biol. 81:102509.
A 6th-year MBSB graduate student, Mr. Jacob Wolfe, in the laboratory of Prof. Seth Horne in the Department of Chemistry at University of Pittsburgh published a review article showing recent uses of artificial backbone connectivity in the design of folded peptide catalysts. Writing a review article during PhD training helps students gain a better picture of the research area that their thesis will inform; it is great that Jacob had the opportunity to complete it before finishing his PhD training. Please read his paper at doi: 10.1016/j.cbpa.2024.102509.
Jacob received Andrew W. Mellon fellowship from 2022 to 2024, and already contributed to an article, “Chemical Shifts of Artificial Monomers Used to Construct Heterogeneous-Backbone Protein Mimetics in Random Coil and Folded States”, Pept Sci (Hoboken). 2023 Mar;115(2):e24297. This is a fundamentally important paper for the future use of backbone chemical shifts from NMR spectroscopy for the structural determination and design of proteins with non-canonical amino acids containing covalent backbone modifications. Highly encouraged to read it at doi: 10.1002/pep2.24297.
http://www.mbsb.pitt.edu/index.php/site-map/articles/85-students/289-jacob-wolfe
https://www.mbsb.pitt.edu/index.php/site-map/articles/81-faculty/162-seth-horne
By MBSB
