Thesis Title: "Single Molecule studies of Damage Recognition by the human UV-damaged DNA-binding protein (UV-DDB)."
Graduation Date: 2013
PhD Advisor: Dr. Bennett Van Houten
Current location: Postdoctoral Researcher at the University of Wollongong, New South Wales, Australia, with Dr. Antoine van Oijen
Education:
B.Tech., Chemical Engineering, Indian Institute of Technology –Bombay, Mumbai, Maharashtra, India, 2007.
M.S., Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, 2008.
Ph.D., Structural Biology & Molecular Biophysics, University of Pittsburgh, 2013
Publications:
- Leuba SH, Carney SM, Dahlburg EM, Eells RJ, Ghodke H, Yanamala N, Schauer G, Klein-Seetharaman J. (2014) Early integration of the individual student in academic activities: a novel classroom concept for graduate education in molecular biophysics and structural biology. BMC Biophys. 2014;7:6
- Ghodke H, Wang H, Hsieh CL, Woldemeskel S, Watkins SC, Rapić-Otrin V, Van Houten B. Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates. Proc Natl Acad Sci U S A. 2014; 111(18):E1862-71
- Godin S, Wier A, Kabbinavar F, Bratton-Palmer DS, Ghodke H, Van Houten B, Vandemark AP, Bernstein KA. The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination.. Nucleic Acids Research. 2013; 41(8):4525-34
- Hughes CD, Wang H, Ghodke H, Simons M, Towheed A, Peng Y, Van Houten B, Kad NM. Real-time single-molecule imaging reveals a direct interaction between UvrC and UvrB on DNA tightropes.. Nucleic Acids Research. 2013
- Paredes E, Zhang X, Ghodke H, Yadavalli VK, Das SR. Backbone-Branched DNA Building Blocks for Facile Angular Control in Nanostructures.. ACS Nano, 2013; 7(5):3953-61.
- Yeh JI, Levine AS, Du S, Chinte U, Ghodke H, Wang H, Shi H, Hsieh CL, Conway JF, Van Houten B, Rapic-Otrin V.Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair. Proc Natl Acad Sci U S A. 2012
- Wang H, Nora GJ, Ghodke H, Opresko PL. Single molecule studies of physiologically relevant telomeric tails reveal POT1 mechanism for promoting G-quadruplex unfolding. J Biol Chem. 2011 Mar 4;286(9):7479-89.
- Siddarth Raman, Harshad Ghodke, Erik Ydstie Modeling and Control of Free Radical Co-Polymerization, ADCHEM 2009.
- Ghodke HB, Krishnan R, Kasinath V, Kumar GV, Narayana C, Krishnan Y, Angew Chem Int Ed, 2007, 46(15), 2646-9.
