Congratulations, Jacob!
20241011
Application of artificial backbone connectivity in the development of metalloenzyme mimics;
Wolfe JA, Horne WS. (2024) Curr Opin Chem Biol. 81:102509.
A 6th-year MBSB graduate student, Mr. Jacob Wolfe, in the laboratory of Prof. Seth Horne in the Department of Chemistry at University of Pittsburgh published a review article showing recent uses of artificial backbone connectivity in the design of folded peptide catalysts. Writing a review article during PhD training helps students gain a better picture of the research area that their thesis will inform; it is great that Jacob had the opportunity to complete it before finishing his PhD training. Please read his paper at doi: 10.1016/j.cbpa.2024.102509.
Jacob received Andrew W. Mellon fellowship from 2022 to 2024, and already contributed to an article, “Chemical Shifts of Artificial Monomers Used to Construct Heterogeneous-Backbone Protein Mimetics in Random Coil and Folded States”, Pept Sci (Hoboken). 2023 Mar;115(2):e24297. This is a fundamentally important paper for the future use of backbone chemical shifts from NMR spectroscopy for the structural determination and design of proteins with non-canonical amino acids containing covalent backbone modifications. Highly encouraged to read it at doi: 10.1002/pep2.24297.
http://www.mbsb.pitt.edu/index.php/site-map/articles/85-students/289-jacob-wolfe
https://www.mbsb.pitt.edu/index.php/site-map/articles/81-faculty/162-seth-horne
By MBSB
Welcome, Grace Kenney!
20240904
Welcome New MBSB Faculty member, Prof Grace Kenney!
Prof. Grace Kenney is a new assistant professor in Department of Chemistry at University of Pittsburgh. Research in the Kenney Lab is driven by a central pair of questions: what types of chemistry are microbes carrying out that we have not uncovered, and how can we best explore this “dark matter” of unknown microbial biochemistry? One major research area is the identification and mechanistic characterization of new classes of enzymes, with a particular focus on metalloenzymes, which carry out complex redox chemistry in diverse cellular pathways. A second area of interest is the isolation and characterization of previously unknown classes of secondary metabolites, particularly bioactive natural products produced in complex microbial communities. Along with structural and biophysical approaches, research in the lab also draws on bioinorganic chemistry, microbiology, and bioinformatics.
Please welcome Grace to MBSB.
https://www.mbsb.pitt.edu/index.php/site-map/articles/81-faculty/396-grace-kenny
By MBSB.
2024 MBSB Symposium!
MBSB Symposium 2024
The eleventh annual MBSB research symposium was held on Wednesday, May 8th from 8:30am to 5:00pm in the Assembly, a biomedical research hub, leased in-part by the University of Pittsburgh. MBSB students organized the symposium. They invited Dr. Nancy Carrasco, Professor, Molecular Physiology and Biophysics at Vanderbilt University School of Medicine, to be the keynote speaker. MBSB faculty, current MBSB graduate students and an MBSB alumnus gave talks. We all enjoyed the symposium. Thank you for planning this nice event!
https://mbsb.pitt.edu/index.php/mbsb-symposium-2024
By MBSB
Thank you, SURP students!
20240727
Thank you for your hard work!
The Summer Undergraduate Research Program (SURP) at the University of Pittsburgh School of Medicine concluded on July 26, 2024. There were three SURP students who worked in the Molecular Biophysics and Structural Biology (MBSB) graduate program laboratories. Together with the students in the Molecular Genetics and Developmental Biology (MGDB) graduate program, they presented their research in the closing-day presentation. We were all impressed by their productivities this summer.
Please check our undergraduate Research opportunity website;
http://www.mbsb.pitt.edu/index.php/training/undergraduate-research
By MBSB.
Congrats to Darian Yang!
20240120
Poster award in the 2024 Gordon Research Conference on Protein Folding Dynamics in Galveston!
Mr. Darian Yang, a 5th year PhD candidate in the MBSB graduate program, co-mentored by Dr. Lillian Chong and Dr. Angela Gronenborn, attended the 2024 GRC: Protein Folding Dynamics in Galveston, Texas, where he received a poster award for his research project titled “Characterization of an Alternate Conformation of the HIV-1 Capsid Protein CTD Dimer using 19F NMR and Weighted Ensemble MD”.
Congratulations, Darian!
http://www.mbsb.pitt.edu/index.php/site-map/articles/81-faculty/146-lillian-chong
http://www.mbsb.pitt.edu/index.php/site-map/articles/81-faculty/156-angela-gronenborn
http://www.mbsb.pitt.edu/index.php/site-map/articles/85-students/290-darian-yang
By MBSB
