20241028

Best Poster Award at the Kinetoplastid Molecular Cell Biology Meeting in Woods Hole, MA

Sophia Staggers, a fourth-year student in the MBSB Program mentored by Dr. Stella Sun, presented a poster and received the Best Poster Award at the Kinetoplastid Molecular Cell Biology Meeting in Woods Hole, MA. In her poster titled “Elucidating the Spatial Organization of Intraflagellar Transport at the flagellum base in Trypanosoma brucei”, she presented on the dynamics of flagellar protein complexes in the T. brucei parasite revealed by cryo-electron tomography (cryo-ET) and ultrastructure expansion microscopy.

Congratulations, Sophia

Please check the student and faculty websites;

https://www.mbsb.pitt.edu/index.php/site-map/articles/85-students/340-sophia-staggers

https://www.mbsb.pitt.edu/index.php/site-map/articles/81-faculty/359-stella-sun

 

By MBSB.


 

The eleventh annual MBSB research symposium will be held on Wednesday, May 8th from 8:30am to 5:00pm in the Assembly.  The 2024 symposium will feature Dr. Nancy Carrasco as the keynote speaker.  Other speakers will include MBSB faculty, current MBSB graduate students, and an MBSB alumnus.  Scroll down to see the schedule of events!

 

Keynote Speaker: 

Nancy Carrasco, M.D.
Vanderbilt University

"The tale of the sodium/iodide symporter (NIS): From cloning to structure"   

 

 

Program Details - MBSB Symposium 2024

 

8:30-9:00 Breakfast

9:00-9:10 Program Welcome

 

Morning Session 1:

Chaired by Awishi Mondal

 

9:10 am              Small Molecule Allosteric Inhibitors for Src-Family Kinases in AML: Developing Novel

                        Inhibitors which Harness Natural Regulatory Networks
                            Ari Selzer

 

9:30 am              Recruitment and assembly of DNA damage checkpoint signaling factors
                            Emily Beckwitt, PhD

                        Postdoctoral Associate, The Rockefeller University

 

10:05 am            42 Years in the Making:  Molecular Movies of GTP Hydrolysis by NRAS and its Oncogenic Mutants
Guillermo Calero, PhD
Associate Professor, Department of Structural Biology

 

10:40 am            Break

 

Morning Session 2:

Chaired by Benjamin Wang

 

11:00 am            Characterizing an Alternate Conformation of the HIV-1 Capsid Protein CTD Dimer using 19F NMR and Weighted Ensemble MD 
Darian Yang

 

11:20 am             Of HEMEs and HETEs: Targeting fatty acid metabolizing cytochrome P450 enzymes to treat human disease
Simone Brixius-Anderko
Assistant Professor, Department of Pharmaceutical Sciences

12:00pm            Lunch

 

12:45 pm             Career Development session for Students (Auditorium)

Afternoon Session:

Chaired by Victor So

 

2:00 pm               Thymine DNA glycosylase combines sliding and hopping to efficiently search for 5-

                        formylcytosine
                            Brittani Schnable

 

2:20 pm              Coarsening of nuclear condensates is governed by the interplay between condensate material properties and chromatin heterogeneity

Huaiying Zhang, PhD
Assistant Professor, Department of Biological Sciences

 

Keynote Address:

Chaired by Sophia Staggers

 

3:00 pm             The tale of the sodium/iodide symporter (NIS): From cloning to structure
                            Nancy Carrasco, PhD
                            Joe C. Davis Chair in Biomedical Science, Vanderbilt University
                            Chair of the Department of Molecular Physiology and Biophysics 
                            Professor, Molecular Physiology and Biophysics

4:00pm               Poster Session + Reception

 

 


 

 


The ninth annual MBSB research symposium will be held on Friday, May 6th from 9:00am to 5:00pm in the Frick Fine Arts Building.  The 2022 symposium will feature Dr. Yifan Cheng as the keynote speaker.  Other speakers will include MBSB faculty, current MBSB graduate students, and an MBSB alumnus.  Scroll down to see the schedule of events!

The 2022 symposium will feature Dr. Yifan Cheng as the keynote speaker. Other speakers will include MBSB faculty, current MBSB graduate students, and an MBSB alumnus.  Scroll down to see the schedule of events!


 

Keynote Speaker: 

Dr. Yifan Cheng

"Single particle cryo-EM studies of TRPV1: from atomic structures to mechanism of channel gating 

 


Registration Information

 MBSB Symposium 2021 registration form and abstract submissions should be completed no later than April 22rd, 2022.

Completed forms should be emailed to Ari Selzer at ars289@pitt.edu

 Registration Form: Click HERE to register!!

Abstract Template: Click HERE to download 

 


Program Details - MBSB Symposium 2022

 

9:00-9:10 Program Welcome


Morning Session 1:

Chaired by Anna Belford

9:10 am           Investigating the activity of G-quadruplex binding protein BG4.
                        Samuel Johnson

 

9:30 am           Characterization of the ABC methionine transporter from Neisseria meningitidis reveals that lipidated MetQ is required for interaction.
                        Naima Sharaf
                        Assistant Professor, Department of Biology, Stanford University
                         

10:15 am          Parallel Session: Career Development session for Students
                         MBSB Faculty Meeting for Faculty


Morning Session 2:

Chaired by Michael Dalton

11:30 am         Watching DNA repair in real time: from cells to single molecules.
                       Ben Van Houten
                       Richard M. Cyert Professor of Molecular Oncology and is in the Department of Pharmacology and Chemical Biology.
                                                

12:05 pm          Parasitic Adaptation of a CCP-Scaffold to Mimic TGB-Beta Immunosuppressive Signaling
                         Ananya Mukundan
                         

Lunch Break: 12:25pm - 1:15pm


Afternoon Session:

Chaired by Brittani Schnable

1:15 pm            Nanoscale Imaging of Biological systems using Molecule Anchorable Gel-enabled Nanoscale In-situ Fluorescence Microscopy.
                         Yongxin (Leon) Zhao
                         Eberly Family Associate Professor of Biological Sciences, Department of Biological Sciences, Carnegie Mellon University

 

1:50 pm             Developing Spin-labels for In-Cell Measurements and Orthogonal Labelling Schemes.
                          Zikri Hasanbasri
                         

2:10 pm             Atomic-level characterization of SARS-CoV-2 spike activation.
                          Lillian Chong
                          Associate Professor, Department of Chemistry, University of Pittsburgh

2:45-3:45          Poster Session

Keynote Address:

Chaired by Ari Selzer

3:45 pm            Single particle cryo-EM studies of TRPV1: from atomic structures to mechanism of channel gating
                         Yifan Cheng
                         Professor, Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California San Francisco


4:45 pm Reception

 

 

Check back for schedule details 


 

 


The tenth annual MBSB research symposium will be held on Friday, May 12th from 8:30am to 5:00pm in the Frick Fine Arts Building.  The 2023 symposium will feature Dr. Clifford Brangwynne as the keynote speaker.  Other speakers will include MBSB faculty, current MBSB graduate students, and an MBSB alumnus.  Scroll down to see the schedule of events!



 

Keynote Speaker: 

Clifford P. Brangwynne, PhD

"Living Droplets: A liquid phase paradigm for biological organization 

 


Registration Information

 MBSB Symposium 2023 registration form and abstract submissions should be completed no later than April 21st, 2023.

For any questions, please contact: MBSBsymposium@gmail.com

All students, faculty and staff welcome. Register today at: https://forms.gle/8wsuZAiBE62Q6Sir5

Abstract Template: Click HERE to download 

 


Program Details - MBSB Symposium 2023

 

8:30-9:00 Breakfast

9:00-9:10 Program Welcome

 

Morning Session 1:

Chaired by Sophia Staggers

9:10 am             Structural basis for biosynthesis of monomeric BMP-9 and BMP-10
                          Tristin Schwartze

 

9:30 am             Why biomembranes find lipid asymmetry pretty stressful
                          Markus Deserno, PhD
                          Professor, Department of Physics, Carnegie Mellon University

 

10:05 am           Break

10:20 am           Parallel Sessions: Career Development session for Students

MBSB Faculty Meeting for Faculty

 

Morning Session 2:

Chaired by Victor So

11:30 am           Structural biology of the TGF-betas:  new insights into mechanism to novel therapies for human disease
                         Andy Hinck, PhD
                         Professor, Department of Structural Biology

12:05 pm           Structural Impacts of Homodimerization Interface Mutations on HIV-1 Nef

Kasia Thomas

12:25pm            Lunch

 

Afternoon Session:

Chaired by Anna Belford

1:15 pm             SARS-CoV-2 Antiviral Development
                          Ryan Slack, PhD

1:50 pm             Development of Novel Gene Delivery Vehicles
                          Yu Hong Wang

 

2:10 pm             Molecular mechanisms of synaptic vesicle transport proteins
                          Jonathan Coleman, PhD
                          Assistant Professor, Department of Structural Biology

2:45-3:00           Break

 

Keynote Address:

Chaired by Michael Dalton

 

3:00 pm             Living Droplets: A liquid phase paradigm for biological organization
                          Clifford P. Brangwynne, PhD
                         
June K. Wu 92’ Professor in Engineering, Princeton University
                         
Professor of Chemical and Biological Engineering
                         
Director, Princeton Bioengineering Initiative
                         
Investigator, Howard Hughes Medical Institute

4:00pm              Poster Session + Reception

 

 

 

 


The eighth annual MBSB research symposium will be held on Friday, May 14th, virtually,  from 9:00am to 5:00pm. The symposium will be held on gather.town (https://gather.town/i/4tog0X3T).  The 2021 symposium will feature Dr. Gregory Petsko as the keynote speaker. Other speakers will include MBSB faculty, current MBSB graduate students, and an MBSB alumnus.  Scroll down to see the schedule of events!


 

Keynote Speaker: 

Dr. Gregory Petsko, Professor of Neurology, Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham & Women's Hospital

"How Parkinson's Disease Starts - And How It Might be Stopped."  

 


Registration Information

 MBSB Symposium 2021 registration form and abstract submissions should be completed no later than April 23rd, 2021.

Completed forms should be emailed to Ananya Mukundan at Mukundan.Ananya@medstudent.pitt.edu

 Registration Form: Click HERE to register

Abstract Template: Click HERE to download 

 


Program Details - MBSB Symposium 2021

 

9:00-9:10 Program Welcome

Morning Session 1:

Chaired by Ari Selzer

9:10 am            Title TBA
                         Maria Kurnikova
                         Department of Chemistry, Carnegie Mellon University, MBSB Training Faculty

9:35 am            Peeking and Poking at Cells: Optochemical Control of Biological Processes
                         Alex Deiters
                         Department of Chemistry, University of Pittsburgh, MBSB Training Faculty

10:00 am          Parallel Session: Career Development session for Students
                         MBSB Faculty Meeting for Faculty

 

Morning Session 2:

Chaired by Ananya Mukundan

11:00 am          Sub-Pocket EXplorer (SubPEx): a Weighted ensemble algorithm to sample protein conformations
                         Erich Hellemann Holguin
                         Department of Biological Sciences, University of Pittsburgh, MBSB student

11:20 am          Holding it Together: Contact Tracing within the NHEJ Synaptic Complex
                         Sean Carney
                         Department of Biological Chemistry and Molecular Pharmacology, Loparo Laboratory, Harvard University, MBSB Alumnus

Lunch Break: 12:00pm - 1:00pm

Afternoon Session:

Chaired by Brittani Schnable

1:00 pm             Activation of Tec family kinase Btk by HIV-1 Nef
                          Manish Aryal
                          Department of Microbiology and Molecular Genetics, University of Pittsburgh, MBSB Student

1:20 pm             Tetramerization: a new paradigm for regulating SNX-BAR membrane interaction
                          Marijn Ford
                          Department of Cell Biology, University of Pittsburgh, MBSB Training Faculty

1:45 pm             Pull yourself together! Mapping mechantransduction of cellular tension forces.
                          Kirill Lavernyuk
                          Department of Chemical Engineering, Carnegie Mellon University, MBSB Student

2:10-3:15           Poster Session

Keynote Address:

Chaired by Ananya Mukundan

 3:20 pm            How Parkinson's Disease Starts - And how It Might be Stopped.
                          Gregory Petsko
                          Professor of Neurology, Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham & Women's Hospital